We therefore believe that the benchtop-scale analysis described herein presents an important and useful tool to identify bottlenecks and optimization targets within the process with reasonable effort and expenditure.
The filtering system presented in this work enables consistent sample collection and concentration from 1 L to 1 mL in five minutes, allowing for subsequent benchtop sample extraction and analysis using molecular methods such as NASBA and IC-NASBA.
Kokosis, G, Phillips, BT, Soo, J, Poveromo, L, Erdmann, D, Mantyh, CR, Migaly, J, and Levinson, H. "Modified V-Y Fasciocutaneous Flap Reconstruction After Abdominoperineal Resection in Irradiated Patients Prevents Wound Dehiscence and Associated Complications: A Retrospective Analysis and Benchtop Confirmation". Annals of Plastic Surgery 82, no. 2 (February 2019): 218-223.
Clinical diagnostic or time-sensitive investigations may require low-throughput, 'on demand' sequencing and automated analysis — on benchtop or even portable sequencers — to deliver actionable results to clinicians.
To our knowledge, this is the first demonstration that employs a convenient and relatively inexpensive, antibody-free nanopore platform coupled to benchtop MALDI-TOF-MS analysis, to isolate and quantify CFP-10 from MTB cultures with a low detection limit.
In this study, an integrative process analysis of a benchtop SHCF is presented.
A compact dual-mode instrument with the flexibility to make well-correlated chemical and structural measurements away from the benchtop would further simplify sample analysis.
In contrast, Mendeliome sequencing and other targeted NGS panels could be established in any molecular genetic laboratory and can be run by benchtop NGS machines while the data analysis can be performed on up-to-date standard computers.
Based on the detailed mass balance analysis of the integrated benchtop SHCF process and the resulting understanding of the process streams, it was possible to identify three key parameters which exhibit a significant influence on YEthanol-Process, the enzyme yield, ηGlucose, and ηHandling.
