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For all benchmarks, we use four structure alignment tools to generate reference alignments: TM-align (Zhang and Skolnick, 2005), Matt (Menke et al., 2008), Dali (Holm and Sander, 1993) and our in-house structure alignment tool DeepAlign.
As benchmarks, we use BRUTE, the 'brute force' method using the Bonferroni correction, BRUTE-WY, the Westfall Young version of BRUTE, and UFE, the univariate Fisher's Exact Test, which only checks for a significant difference in single SNPs.
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With the Gene Ontology (GO) annotations [33] and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotations [34] as benchmarks, we used annotation overlap rates (see Methods and Materials) to validate the reliability of the protein pair ranking from P1, and preliminarily determined functionally associated protein pairs (i.e., significant protein pairs).
For all benchmarks, we used one or more dedicated Dell Blade M605 compute nodes with 2 quad-core Opteron 2.33 GHz processors and 24 GB of random access memory.
We performed benchmarking tests on a large set of nucleic acid and protein sequences For protein benchmarks we used the benchmark database BALIBASE 3 and an updated release of the database IRMBASE 2 for assessing the quality on globally and locally related sequences, respectively.
As benchmarks we used not only the DREAM4 In Silico Network challenge but also a novel and unprecedented synthetic compendium consisting of several realistic 5000-gene networksimulateded with varying biological and measurement error variances resulting in a total of 270 datasets.
As a benchmark we use the control of a flexible arm which carries a payload along a horizontal circular trajectory with a perfect damping of the vibration at the stop.
What should be the normative benchmark we use when evaluating the welfare implications of policy initiatives?
As benchmark, we use the FER of a reference system with (K,Kp) = (200,0) where the channel coefficient h is known to the receiver.
To evaluate the proposed HRMIR approach, extensive experiments have been conducted, and as benchmark, we use conventional Optimal Intra Refreshment [6] and RS-MDC [9] for comparison.
The benchmark we use is: Does it interfere with quality of life?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com