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Rather than reproducing known standard clinical measurements, such as the prothrombin time and activated partial thromboplastin time clotting tests, the anticoagulant benchmarking was based on a simulation of physiologically plausible clotting scenarios.
Data collection for the benchmarking was based on a literature review, including grey literature such as reports from international or national institutions, and on consulting stakeholders in each of the countries.
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Most approaches used for energy benchmarking are based on statistical methods by comparing with a sample of existing plants.
Benchmarking is based on different levels of collaboration recognized in the typical product development process in SMEs.
The most commonly used prediction models for mortality benchmarking are based on vital signs and injury pattern, including the Trauma and Injury Severity Score (TRISS), which is less accurate in the elderly.
The targets set for the critical quality indicators (HbA1c, LDL-cholesterol and SBP) used for benchmarking were based on international guidelines [ 16- 18], and, when deemed necessary, adapted by the study steering committee in order to be consensual to the participating countries (Table 1).
One underlying reason is that PSI's CSE methodology developed so far and previously applied for this benchmark was based on using a more conventional approach, involving engineering guesses in order to estimate uncertainties in the calculated effective multiplication factor (keff).
The promoter benchmark was based on the RefSeq gene annotations taken from the RefGene table of the hg18 genome assembly downloaded from the UCSC Genome Browser on October 22, 2009.
Our benchmark was based on 470 RNAse P structures, ranging across various organisms, taken from the RNAse P database [ 53] (molecule naming conventions are according to [ 50]).
Our benchmark was based on 146 Hammerhead structures (86 of type I and 62 of type III), ranging across various organisms, taken from the RNA Strand database [ 50].
But if the benchmark is based on the Mayo ratio, we can project an excess of nearly 50,000 doctors in the year 2020.
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