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They also suggested that benchmarking effects are likely to be larger where baseline compliance with recommended practice is low (37), which may have been a feature of OPTIMISE given that the reported percentages of achievement of the vascular risk targets at the start of the study were low.
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41 It extends our previous study by examining the effect of the course on depression and anxiety symptoms, benchmarking the effects against other studies by using measures that are now widely used in primary care practices in the UK.
A caveat in the application of the mathematical benchmarks, effect size and NNT, is the influence of trial design, outcome measures and patient population on the apparent magnitude of response to a given treatment.
In an earlier study we benchmarked the effect of varying cost and γ when doing classification using the SVM and the RBF kernel with the result that a sweet spot is located around cost = 10 and γ = 0.01 [21].
This data serves as a valuable source for building in silico models for predicting polypharmacology and off-target effects, and benchmarking the prediction performance and computation speed of machine-learning algorithms.
There are limited publications on the effects of benchmarking on quality of care in T2DM.
To assess prospectively the effect of benchmarking on quality of primary care for patients with type 2 diabetes by using three major modifiable cardiovascular risk factors as critical quality indicators.
The OPTIMISE (OPtimal Type 2 dIabetes Management Including benchmarking and Standard trEatment) study was initiated (15) to assess prospectively in a randomized, controlled trial the effect of benchmarking on the quality of primary care for patients with type 2 diabetes and its impact on achieving preset targets.
The 14 preliminary hit compounds were independently assessed for their influence on cell viability, with effects benchmarked to the EGFR-inhibiting agents erlotinib and cetuximab.
Going forward, it will be important to develop a yardstick for benchmarking the magnitude of the effects we are observing.
Also benchmarking could have a positive effect on quality as well.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com