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Lower values were obtained with the logarithmic curve, and higher results with a larger benchmark response.
The benchmark response (BMR) was defined as a 10%% additional risk above the background.
One standard deviation (1SD) from the control mean was chosen as the benchmark response (BMD1SD) level.
A crucial aspect of the BMD method is the specification of the benchmark response (BMR) level associated with the BMD.
Assumption of no effect below the lowest observed dose resulted in higher benchmark dose results, as did a benchmark response of 10%.
The BMD is an exposure level at which one observes a prespecified amount of response [e.g., the benchmark response (BMR)] in a population.
Similar(30)
This paper investigates the effectiveness of several NSPs in predicting the salient response characteristics of typical steel and reinforced concrete (RC) buildings through comparison with benchmark responses obtained from a comprehensive set of NTH analyses.
We compared batch-calculated BMD/Ls based on a standardized, guidance-driven choice of benchmark responses and models with BMD/Ls based on chemical-specific decisions made by different assessors and at different times.
Equal numbers were randomised to BEP to benchmark contemporary response rates.
The control cereal species, used to benchmark the response of the T. monococcum accessions, performed as expected.
As a substitute for the NOAEL of the most sensitive endpoint (TM renal clearance), a hybrid benchmark dose response of 10% above background (BD10) was derived using the Fortran program BENCH_C (Crump 1995; Crump and Van Landingham 1996).
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