Because BEN takes decades to develop, investigators are always following a cold trail, and this makes the disease a particularly intractable puzzle.
"Because BEN takes decades to develop, investigators are always following a cold trail," Batuman writes, "and this makes the disease a particularly intractable puzzle.
Twenty years later, some of the Karash exiles began to develop BEN, but those who had moved as children never got the disease — only those who had lived in Karash for fifteen years or more.
For example, the gene-environment interaction is translated into unusual xenobiotic substance metabolism (controlled by cytochrome P450 and other enzymes) that increases the risk to develop BEN only in those individuals that bear certain gene variants that code for the detoxification enzymes (Atanasova et al. 2005).
The relatively low concentrations of compounds (in the ng to μg/g range) present in samples, however, may provide a plausible explanation for the extended time required for kidney failure and upper urinary tract cancer to develop in BEN patients.
Knockout mice of claudin-14 were demonstrated to develop deafness (Ben-Yosef et al., 2003).
Designed to extinguish any spark of counterplay, this Ben-Oni variation also makes it difficult for black to develop.
Ben-Shaul, like the Daniels, felt some ambivalence about the form, even as he sought to develop it.
Because Ben-Tal's formulation leads to a non-linear model and no guarantee regarding the probability that the robust solution is feasible, it is highly desirable to develop a method that addresses these drawbacks.
An argument against this option is that we have found reduced kidney sizes and increased protein excretion in the BEN offspring, which may be considered as early signs of BEN [ 14]. (II) BEN offspring will develop BEN and their higher average blood pressure will disappear with the progression of BEN.
