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We also acknowledge that the choice of the breakpoint used in the survival analysis (above vs. below the upper quartile) was data driven.
**Low Responders are defined as those individuals who fell below the upper quartile of percent change in rVO2 max.
The mean percent change in rVO2 max was calculated and individuals who fell in the upper quartile (upper 25%) of percent change in rVO2 max were labeled as high-responders (10 individuals) and those who fell below the upper quartile were considered low-responders (9 individuals).
Also, in women with no insulin resistance as identified by HOMA < 2.8 or IGFBP-3 below the upper quartile (4.6 μg/mL), metformin exhibited a trend to an increase in ki-67 compared to placebo, although the IQR range included negative values.
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Additionally, mice were excluded after the experiment if they were statistical outliers (below lower quartile −1.5× the interquartile range or above the upper quartile + 1.5 × interquartile range) on displacement relative to their experimental grouping (2 mice) or if they demonstrated evidence of plantar stepping immediately post injury (3 mice) (BMS score ≥ 4), both a priori exclusion criteria.
High income was above the upper quartile of the income distribution, low income below the lower quartile and medium income comprised the values in between.
Subsequently, it was checked whether this distance was below or above a cut-off value of 2.25 times the distance of the upper quartile to the mean of the BLOSUM62 distances among the reference species.
"If you look at the upper quartile and the lower quartile, you know that those people are not interchangeable".
Boxes are drawn from the lower quartile to the upper quartile, with a line at the median.
The curves are split on the basis of the upper quartile of clonal neoantigen burden (a), on the upper quartile of subclonal neoantigen burden (c) and on the upper quartile of total neoantigen burden (e).
The maximum tariff point will be the upper quartile of the subject's average tariff points.
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