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Data from patients with week 4 Cτ values below the threshold selected based on differences in PFS or mean maximum tumour reduction were removed.
Although with ALU values below the threshold selected for this screening (ALU ≤ -0,643; lowest 1% of total), 12 Keio LPS mutants showed negative ALU values suggesting a defect in recipient ability.
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We simulated 60 genes with each fold change to generate (1) 600 genes with fold changes greater than 2.0 (to reflect the approximate number of differentially expressed genes in the real data), and (2) 600 additional genes with fold changes below 2.0, the threshold we selected for differentially expressed genes.
The compounds having docking score below the threshold value (−9.0) were selected.
But, all the normalized hamming distances are below the selected threshold.
Moreover, the few lost hit genes had high FDR values, just slightly below the selected threshold FDR < 0.4.
Deforestation is then implied when canopy cover falls below the selected threshold.
An empirical cumulative distribution function of the maximum tumour shrinkage relative to baseline for patients with Cτ values above and below the selected threshold value was constructed.
Several motifs had significant matches, with dissimilarity scores below the selected threshold of 1.3, and p-values less than 0.05 (Table 1).
In case there were no probesets below the Bonferroni threshold, we selected those four probesets that displayed the highest fold changes.
The spectrum thresholding includes a single routine for cutting off the peaks that are found below the selected intensity threshold.
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