If depolarization reaches what is called the threshold potential, it triggers the nerve impulse, or action potential see below.
Although some authors have reported combining a very high AMK regimen (50 mg/kg) with high-flow CRRT to obtain adequate Cpeak/MIC and rapidly reduce drug concentrations below the threshold of potential toxicity [ 24], this approach needs to be further validated and the choice of another antimicrobial should be considered for strains with MICs 8 to 16 mg/L.
Neuronal voltage-gated (Kv) potassium channels that open at membrane potentials close to the threshold for action potential generation have a profound effect on neuronal excitability because of their ability to stabilize membrane potentials below the threshold for action potential initiation.
However, despite its larger amplitude, the EPSP generated by the EC inputs is still below the threshold for action potential firing (using somatic current pulses).
As the potential is decreased to more negative values, a limiting-current behaviour is observed followed by film breakdown below a certain threshold potential.
Miranda et al. (2006) used inverse modelling to show that 1mA of tDCs leads to about 110 µV/mm of electric fields in cortex, thus probably staying below the threshold for action potentials [55].(Note, however, that already tDCS intensities of 2mA can exceed this threshold).
However, the observation that some neurons can release functionally significant amounts of neurotransmitter below the threshold of action potentials questioned the possible involvement of another source of Ca2+ ions, independent of HVA channels activation.
This potential is below the threshold at which an action potential is triggered in the muscle cell and thus does not lead to muscle contraction.
The mechanistic link between transduction and amplification by JONs was recently put into question because 'active amplification is observable for intensities below the threshold for antennal field potential responses' [ 15 ].
Because of the possibility of such joint effects, screening benchmarks are sometimes set below the thresholds at which potential individual effects might occur.
