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Where available (n = 4), the estimated fetal dose was below the threshold dose (<0.1 Gy).
Maternal exposures in our study may have been below the threshold dose required for development of hypospadias.
We postulate that for some subjects in Panel B, 7.5mg of prednisone may be just below the threshold dose for a sustained anti-inflammatory effect.
EFSA (2006) concluded that the mechanism for carcinogenic response of OTA was most likely threshold based, the significance being that low doses below the threshold dose would not be associated with a cancer risk.
Previous research demonstrated that a mixture of 11 pyrethroids had a dose-additive effect on the rat nervous system, decreasing the animals' motor activity at doses below the threshold dose of each constituent compound.
In recent years, the introduction of stereotactic ablative radiotherapy (SABR) has offered even more intensive tumor dose escalation using a hypofractionated regimen with reduced dose to the normal liver, usually below the threshold dose above which severe RILD is observed.
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A dose of below 4 Gy appears to be the threshold dose, depending also on the associated treatment.
These distributions are combined into an overall log-normal distribution for the threshold dose (dose below which there is no contribution to a toxic response) by assuming the variables act independently and multiplicatively.
In this case, the haploinsufficiency of CLB2 in the diploid would be due to the heterozygous deletion taking the concentration below this threshold dose.
The total amount of hydroxyethyl starch remained largely below the safety threshold dose even when both fluid challenges were carried out [ 25].
The lowest dose level in the trial was therefore likely to have been below the minimum effective threshold dose and above this level there was little evidence of a DI effect.
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