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Patients with non-transfusion-dependent thalassemia (NTDT) often develop iron overload that requires chelation to levels below the threshold associated with complications.
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A 1°C decrease in temperature (lag 0 6 days) below the threshold was associated with 0.8% increase in cerebrovascular mortality, while a 1°C increase in temperature (lag 0) above the threshold associated with 4.7% increase in cerebrovascular mortality [ 34].
The 1-year study established a treatment paradigm for iron-overloaded NTDT patients whereby chelation with deferasirox can be initiated when LIC exceeds 5 mg Fe/g dw and continued with a treatment goal of reducing LIC below a threshold associated with complications [ 2].
They have been below 300,000, a threshold associated with a strengthening labor market, for 10 straight weeks.
In 47.2% (59/125) of patients, the plasma level was below 30 ng/ml, the previously published threshold associated with therapeutic efficacy (12), and the 3 patients with a PCR-confirmed recrudescence had piperaquine levels of 16.3, 31.4, and 33.1 ng/ml, respectively.
Mean Decisional Conflict scores were significantly higher for the web-based version than for the videobooklet; however, the post-decision aid mean for the web-based version (19.5) was below the threshold (25.0) associated with patients who proceed to making decisions [ 42] and reflected a significant improvement from baseline (31.0).
However, under dose addition, combination effects may occur even when all mixture components are present at levels below dose thresholds associated with zero effects.
We checked alignments and in all these cases one or more species yielded a score just below the threshold of 30, usually associated with a much shorter transcript than in the other species.
In another series of brain mapping experiments, modifications in reaction time induced by subliminal stimuli (i.e., that are presented below the threshold of awareness) have been associated with activity changes up to the level of the primary motor cortices, suggesting again that an activation of motor programs can be elicited unconsciously [9], [10], [11].
The European Food Safety Authority (EFSA) concluded that the mechanism for carcinogenic response of OTA was most likely threshold based, the significance being that low doses below the threshold dose would not be associated with a cancer risk (EFSA, 2006).
EFSA (2006) concluded that the mechanism for carcinogenic response of OTA was most likely threshold based, the significance being that low doses below the threshold dose would not be associated with a cancer risk.
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