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This study sets the diagnostic standard, already discussing further possible mechanisms for the formation of microvillus inclusions (ectopic brush border formation at intracellular sites [3] versus engulfment of brush border via autophagy/macropinocytosis [1]; see also below the paragraph on pathophysiology).
For sequence comparison of these two fragments see below the paragraph of "in silico analyses".
We have, however, provided below the paragraph we would have put into the article in response to this part of the reviewer's comment.
See below the paragraph added in the manuscript text: "In order to determine if the ribosome profiling signal in lncRNAs was different from noise, we compared ribosome density in the transcripts it to that in 3'untranslated regions (3'UTRs).
However, when looking for conserved Pfam motifs (see below the paragraph on the putative role of LGRs), we found a conserved domain present in mycoplasmal lipoproteins in LgrA, LgrB, LgrE and LgrF, suggesting that these LGRs exhibit a prokaryotic membrane attachment site probably acting as a membrane anchor [ 25].
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With the approval of the organizer, each attendee of the talk was given an information sheet and a short questionnaire asking about the sampling criteria (see the below paragraph for the inclusion criteria) and their contact methods if they consented to participate in the study.
In this respect, we added the below paragraph to the end of the subsection "Neural substrates": Such orosensory-based approximation of nutritional content, could have been obtained through evolutionary processes (Breslin, 2013), as well as through prior learning (Beeler et al., 2012; Swithers et al., 2009, 2010).
For further details on this crucial part of Kant's argument see Friedman (1992a 1992b 20132013); compare also note 40 below, together with the paragraph to which it is appended and the preceding paragraph.
I would suggest the authors add the reference below into the paragraph 2, first sentence: Bergeron P, Bourget E (1986) Shore topography and spatial partitioning of crevice refuges by sessile epibenthos in an ice disturbed environment.
For the sake of clarity in terminology, in the paragraph below, N is the signal length, N τ is the lag window length, N A is the length of the analysis window, and N w is the average length of adaptive lag window.
In the paragraph below, answer why the area of research is important and identify the type of research or analysis proposed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com