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Importantly this continual dosage is likely to occur far below the Minimum effective dose at a concentration that has classically been thought subtherapeutic.
Because of these fluctuations in drug plasma levels, the drug concentration could fall below the minimum effective concentration or exceed the minimum toxic concentration.
Observations on the solid black area of the nomogram were identified as corresponding to atazanavir exposure below the minimum effective concentration (MEC).
The level above maximum safety concentration would lead to toxicity and level below the minimum effective concentration results in lack of efficacy.
Levels above the minimal tolerated concentration may result in serious toxicity, and levels below the minimum effective concentration will be subtherapeutic.
A pharmacokinetic study has recently shown that in cotreated patients, nevirapine concentration was below the minimum effective concentration during initiation with dose escalation.
Similar(52)
Importantly this effective low continual dose likely occurs much further below the drug dose classically defined as the 'Minimum effective dose'.
This required, at the minimum, effective control of national unions over the shop floor.
25 mg sumatriptan was the minimum effective dose [6].
Dr. Green has the philosophy of prescribing the minimum effective dose.
The minimum effective resolution is the selected criterion.
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CEO of Professional Science Editing for Scientists @ prosciediting.com