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Two other patients developed IgM concentrations below the lower normal limit of 0.4 g/L.
A major decrease in LVEF was defined as an absolute decrease to at least 15% below the lower normal limit.
Two patients out of the six who were negative by EBNA-1 ELISA, had total IgG levels below the lower normal value (570 and 252 mg/dL with normal range between 624 1680 mg/dL).
None of the patients with a drop of any Ig isotype below the lower normal limit developed clinical symptoms of immunodeficiency, but seven of these patients experienced good clinical response and one patient experienced moderate clinical response.
Subgroup analysis of all measurements with GEDI below the lower normal level 680 ml/kg/m2 demonstrated an independent association of CI to GEDI (P < 0.001), dPmax (P < 0.001) and ELWI (P = 0.041) but not to CVP.
Trastuzumab administration was also withheld in the event of a decline in LVEF value either ⩾20% of absolute units from baseline to a value above the lower normal limit for the centre, or ⩾10% of absolute units to a value below the lower normal limit for the centre.
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Airway obstruction was defined as forced expiratory volume/forced vital capacity (FEV1/FVC) below the lower limit of normal (LLN) with a normal FVC.
In 31 patients from the study group, a mild degree of obstruction was determined (forced expiratory volume in 1 second – FEV1 > 80% normal value; the FEV1/FVC ratio below the lower limit of normal, where FVC is the forced vital capacity of the lungs), while, in 39 subjects, the degree was moderate (50% normal value < FEV1 < 80% normal value; the FEV1/FVC ratio below the lower limit of normal).
Milrinone significantly increased CI and decreased SVR in the high pre-CPB CI/milrinone group: 10 of the 12 patients had CIs above the upper limit of normal, and 7 patients had SVRs below the lower limit of normal.
The APC/PC ratio did not fall below the lower limit of normal in any sample but exceeded the upper normal limit in 40% of the samples.
This included patients who were breast feeding or pregnant; had chronic liver or kidney disease; had cytopenia (below the lower limit of normal) or transaminitis (aminotransferases above the upper limit of normal); had active infection, including but not restricted to HIV, or hepatitis B or C, or active tuberculosis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com