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Patients whose preoperative hemoglobin was below the local laboratory reference values (i.e. < 117 g/L in women and < 136 g/L in men) were considered to have anemia.
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All but three patients had at least one low lymphocyte value, generally at one and two weeks after infusion; however, eight patients (44%) had lymphocyte counts below the local laboratories' normal ranges, (but above the level stated in the exclusion criteria) before infusion of MRA.
If red cell folate is also below the normal range for the local laboratory, then we shall exclude the participant from the trial, but include him or her in the 'comprehensive cohort study' for follow-up during (unblinded) folate supplementation.
Further restriction of dietary calcium (by also avoiding foods prepared with milk, such as smashed potatoes, bread, cakes and cookies) dropped urinary calcium to levels below the lower limit of the normal range adopted by the local laboratory (100 mg or 2.5 mmol per day) while serum calcium remained around the lower limit (8.6 mg/dL or 2.15 mmol/L).
Anemia was defined as Hb below the lower reference value (according to age and gender) of the local laboratory (Additional file 1: Table S1).
The fruits of C. annuum were collected from the local laboratory cultures in western Romania.
E.K. performed the local laboratory determination.
All laboratory assays were performed by the local laboratory using standard laboratory methods.
The total cholesterol level was examined by the local laboratory and not by one central laboratory.
Some agents isolated in the local laboratory, Salmonella and Shigella could not be confirmed by the national microbiology reference laboratory.
The local laboratories in the CS multi-country study performed well.
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