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Because the effect concentrations of human or synthetic hormones are often below the limits of quantitation (LOQs) of analytical methods, these substances are analytically difficult to monitor but their effects can be measured with specifically designed assays [12].
Since most PAHs in elutriates and seawater used for sediment extraction were below the limits of quantitation [LOQ] and LOD, with the exception of PYR, BAA and CHR in the elutriate prepared from the sediment sample from Marseille, the equilibrium concentrations in the elutriates were calculated.
All concentrations that were below the limits of quantitation (BLQ) were set to zero before computation of descriptive statistics (BLQ values were excluded from the calculations of geometric means and the associated 95% confidence intervals).
In order to understand the nature of this residual viremia, a major obstacle needs to be overcome: developing a reliable and consistent method to characterize the residual HIV in plasma when viral loads are low and below the limits of quantitation.
Only PGE2 stimulated HGF secretion by FBs (n = 3) (Fig. 5 C ). MS analysis also showed that other arachidonic acid metabolites such as 5-HETE and 15-HETE were induced by influenza-infected AECs (Fig. 5 B ), whereas LTB4 and LTE4 were below the limits of quantitation.
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The limits of quantitation (LOQ) and (LOD) were calculated according to ICH Q2 (recommendationtion [34].
below the limit of quantitation.
For all calculations, values that were below the lower limit of detection were given an arbitrary value of "1" and those below the limit of quantitation were given an arbitrary value of "5".
Concentrations below the limit of quantitation were set to zero.
Peaks below the limit of quantitation (signal-to-noise ratios <9 1) were excluded from the analysis.
No radiolabel could be detected in plasma since all samples were below the limit of quantitation.
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