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In the example below, the isotopic layer is '/i1 + 1,4 + 1D'.
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The isotopic layer is used when non-standard atomic isotopes are present.
The Isotopic layer (signified with the prefix '/i') identifies different isotopically labeled atoms.
In the mobile H group these hydrogen atoms are treated as non-isotopic; the number of these mobile isotopic hydrogen atoms is appended to the "exchangeable isotopic hydrogen atoms" part of the isotopic layer.
The method denoted Chs- ignores the isotopic layer while the method denoted Ch-I ignores the stereochemistry layer.
Another layer that may be present is the isotopic layer, and there may be an updated canonical label section associated with this.
Note that the isotopic layer may optionally include its own '/s' stereo sublayer, as adding isotopic substitution to the core parent structure may change the stereogenic elements and their configurations.
These are caused by the current lack of support for the isotopic layer as discussed at the end of the Canonical labelling section in the Methods.
The next layer is the isotopic '/i' layer.
The isotopic structural layer is the most straightforward to compute.
For example, the value produced for the stereo layer will depend on whether it was derived from a main layer or Fixed-H layer or whether it belongs to an isotopic layer.
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