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This association was also significant for women aged 50 and over, but there was no trend with increasing pack-years smoked below the highest quartile (Table 2).
Insulin sensitivity has been defined by the World Health Organization (WHO) as values below the highest quartile of the HOMA-IR index, as measured in subjects without diabetes (27).
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We also ascertained census block group information such as median household income, percentage of population living below poverty level (the highest quartile vs. others), and hospital density (i.e., number of hospitals per 100 km in each ozone region) to control for medical care access at the neighborhood level.
A statistically significant association is also evident among those with the highest serum concentration of p,p′-DDT (comparing those above the median level to those below the detectable limit) and p,p′-DDE (comparing those in the highest quartile to those in the lowest quartile of serum concentration).
The men in the highest quartile were also 10.1 times as likely to need angioplasty or bypass surgery.
Employees earn an additional $6,450 a year, or 17% more, at companies in the highest quartile of trust, compared with those in the lowest quartile.
The lowest quartiles of the continuous values of CD66b, CD163, and FOXP3, and the highest quartile of that of CD8 were determined as cut-offs (Supplementary Table S1).
In particular, the countries in the highest quartile of racial/ethnic diversity benefited the most.
FSIQ in the highest quartile was slightly, but not significantly, lower than the median quartiles, but the odds ratio for having a FSIQ score of less than 70 for children in the highest quartile was 3.3 (95% CI 1.2-9.1 1.2-9.1
In contrast, men with high tumor Ki67 (above median, i.e., ≥ 2.7%) and particularly in the highest quartile (quartile 4, ≥ 5.4%) were associated with a poor outcome as earlier described in more detail [12, 15].
Of the people in the lowest quartile, 29% died, versus 17.5% of those in the second quartile, 13.4% in the third quartile, and 9.3% in the highest quartile.
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