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Additional copies of proteins VI and VIII interact below the hexons at the icosahedral twofold axis.
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On the inner capsid surface, a portion of core protein V is found to interact with proteins VI and VIII below the peripentonal hexons.
X-ray crystallography and sequence analysis together reveal the hypervariable regions of hexon at the top of the molecule where the most variation is tolerated.
Additionally, neutralizing antibody is directed at the hexon type-specific antigen and provides some future protection against serotypes [ 74].
Recombination events at similar nucleotide locations of the hexon gene in HAdV-D13, HAdV-D32, and HAdV-D39 (Fig. 3C E) were found.
Previously, sequence variations among the different genome types of Ad7 strains have been observed at 2 variable regions of the hexon gene and in a 14.9-kDa protein encoded by an ORF in the E3 region (6, 14).
A chimeric Ad vector, Ad3/H7, was constructed by replacing the Ad3 hexon gene (H3) with the hexon gene (H7) of Ad7.
Genetic differences were identified within the hexon gene of 17 bearded dragons from 4 collections.
The hexon protein of human adenovirus (HAdV) processes type-specific B-cell neutralizing epitopes.
With the hexon mRNA copy numbers as reference, the fiber to hexon and penton to hexon ratios were 0.97±0.17 and 0.49±0.14, respectively (N = 6, p<0.00001, paired t test) (Figure 5C).
The major capsid component, the hexon, is also involved in hepatocyte infection [13].
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