Sentence examples for below the dose level from inspiring English sources

In case only one patient developed DLT (see below), the dose level was expanded with additional patients to a total of six.

Each drug is administered orally at an initial dose level or below the dose level approved for each drug (aripiprazole, <12 mg/day; blonanserin, <8 mg/day; and paliperidone, <6 mg/day).

The MTD was defined as the dose level immediately below the dose level at which 2 of the first 3 patients per cohort (or ≥2 of 6 patients) experienced a DLT during the first treatment cycle (28 days).

The MTD was defined as that dose level immediately below the dose level at which a minimum of two patients in a cohort of three to six patients experienced DLT.

This is within the recommended range for transplantation indications, i.e., 2 to 6 mg/kg/day, and is below the dose level of 5 mg/kg/day known to potentially increase creatinine and hypertension side effects (13).

If all patients in a cohort of three developed significant haematological or non-haematological toxicity, treatment was stopped and the dose level below was taken as the MTD.

If all three patients at a particular dose level of irinotecan developed significant haematological or nonhaematological toxicity, treatment was stopped and the dose level below was taken as the MTD.

If a DLT was observed in two of the six patients in the expanded group, dose escalation was terminated and the sample size of the dose level below was increased to six patients.

For each docetaxel dose, ombrabulin dose escalation was stopped when two or more patients had DLT during the first cycle, and the dose level immediately below was considered the RP2Ds and expanded with 10 additional patients.

The dose level below the MTD was recommended for phase II evaluation.

The study maximum dose (SMD) was set to 30 mg kg−1 and maximum-tolerated dose (MTD) was defined as the dose level below any dose with >1 DLT.