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For the M=0.9 jet the correlation coefficients fell below the confidence interval for θ= 67°.
If the pWCMC is below the confidence interval for at least one pair, ReVS asks for more runs.
Such placement, if observed, may shift the confidence interval towards higher impact values, thus making the pWCMC to be below the confidence interval for this pair.
The relative risk was 1.00 (95% CI 0.96-1.05) in the randomised trials [ 9], although with the commonly stated 30% reduction in breast cancer mortality with screening, the expected relative risk for all-cancer mortality would be 0.95, which is below the confidence interval of what was actually found [ 9].
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Since, as in the Q profile method below, the confidence intervals are based upon an exact (under the assumptions of the model) distributional result, exact confidence intervals are obtained, subject to the [0,0] or empty set caveat discussed above.
Principles of statistical inference dictate that only individuals with assay values below the lower limit of the confidence interval can confidently be said to be susceptible by the measure, and only those above the upper limit may confidently be said to be protected.
Although best fits suggested values above 0.9 (90% quiescent cells surviving a single treatment) in 18/32 detectable patients, Sq was below 0.5 in six cases and in another six cases the best fit was above but the lower limit of the confidence interval was below 0.5.
The non-inferiority will be supported by the result that the upper bound of the confidence interval is below 1.5.
It is worth noting that the percentages of ARS1 S usage in both CST6 and YAP3 knockout strains are either very close to or slightly below the bottom of the confidence interval.
This will affect the local minimax probability estimate as discussed below but the width of the confidence interval will remain valid.
For the SUVmean values, Bland-Altman plots identified 14 outliers of which 9 had a ratio below the lower limit of the confidence interval (2 tumours, 2 mediastinal nodes, 2 hilar nodes, 2 bone metastases and 1 lung metastasis) and 5 above the upper limit of the confidence interval (1 tumour, 1 hilar node and 3 bone metastases).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com