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The slope is also showing an increasing trend with decreasing temperatures below the change point, but the dependence is threefold smaller.
Spearman's ρs showed positive relations with cognitive impairment both above and below the change point (see Table 2).
Mononucleotide TRs, in particular, have the lowest rate of change and tetranucleotide TRs the highest rate of change below the change point.
Further, in all four TR classes, polymorphism incidence values below the change point are <1%, comparable with those of single nucleotide polymorphisms (SNPs) and indels in nonrepetitive regions, which have polymorphism incidence values of 0.3251% and 0.0164%, respectively.
Inspection of the slope estimates obtained from fitting the segmented regression models (table 1) reveals large differences in slopes below the change point among the four motif sizes, with mononucleotide repeats having the smallest slope (0.52) and tetranucleotide repeats the highest (2.2).
Intriguingly, at repeat numbers below the change point (c), the rate of polymorphism incidence growth (b 1) is high, although the absolute values of polymorphism incidence are low (0.01 1%), whereas at repeat numbers above the change point the rate of polymorphism incidence growth (b2) is low, although the absolute values of polymorphism incidence are high (>1%).
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The different rates of exponential growth in polymorphism incidence below and above the change point potentially reflect the varying contribution of different mechanisms to the mutability of STRs and MSs (discussed later).
For each biomarker, the "Above" and "Below" columns shows values for CAMCOG scores above and below the change-point, respectively.
In summary, the levels and variability of CSF Tau and the slope of its relation with CAMCOG differed above and below the change-point.
In summary, the levels and variability of CSF Aβ1-42 and the slope of its relation with CAMCOG differed above and below the change-point.
In summary, the levels and variability of CSF phospho-Tau and the slope of its relation with CAMCOG differed above and below the change-point.
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Justyna Jupowicz-Kozak
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