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After termination of pyruvate, CI, SVI, and mean SAP tended to drop below the baseline values.
Remarkably, in nine patients, proteinuria fell below the baseline values from before the onset of the recent LN flare.
Patients requiring more than 2 weeks treatment delay for any reason or experiencing a decrease of the LVEF >15% below the baseline values with or without clinical signs of congestive heart failure were withdrawn from the study.
Overall, mean body mass index decreased in both groups between baseline and T1 (intervention 2 points and control 1 point, Table 2) but increased again between T1 and T3, although mean body mass index remained below the baseline values.
In 13 of 20 patients, proteinuria decreased by 50% (Table 8); in 7 patients, to less than 1 g/day (levels on entry: 1.13 to 20.88 g/day); and in 9 patients, proteinuria fell below the baseline values before onset of the recent LN flare.
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After infusion of sodium chloride, both pH and base excess (BE) decreased significantly and remained below the baseline value for the duration of the study.
In this study, CBF fell below the baseline value as brain temperature decreased, remained suppressed throughout the rest of the cooling period, and only returned to the baseline level when the brain was rewarmed to the baseline temperature (Fig. 3f).
When reduced PDI was perfused over a CT-coated SPR sensor slide, an increase in the RIU was followed by a precipitous drop in signal below the baseline value which represented the mass of the CT holotoxin.
Similarly, the Kbone value for whole skeleton returned to below the baseline value at 24 months.
A total of 13 out of 28 (46%) patients achieved a nadir PSA response below the baseline value.
In comparison, in the PR group, improvement in FSS total score to a value comparable to or below the baseline value was not evident until Week 60.
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