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The males showed an age-related significant change in a number of metabolic indexes ranging from food intake to glucose regulation at BPA doses below the no observed adverse effect level (5000 µg/kg/d).
Over the past 15 years, several studies with chemical mixtures (e.g., hormonally active chemicals or pesticides) at concentrations near or below the no observed effect concentration (NOEC) or the NOAEL have reported potentially harmful biologic responses (Cavieres et al. 2002; Rajapakse et al. 2002; Welshons et al. 2003).
Considering this effect culmination enables to link long-term effects of repeated low-dose toxicant pulses at concentrations that should have no effect on the number of individuals within a population (i.e., below the no observed effect concentration for each individual pulse).
Although individual phthalate exposures in humans are generally asserted to be below the no observed effect level (NOEL), combinations of man-made estrogenic chemicals, individually below NOEL concentrations, have been shown to exert considerable effect in a yeast reporter gene assay using the human estrogen receptor-α (Rajapakse et al. 2002).
It is often suggested that low concentrations of environmental pollutants are of no concern because, in most circumstances, concentrations are below the No Observed Effect Levels (NOEL); i.e. environmental levels of each individual chemical have been shown to be below the minimum concentrations known to induce a physiological response.
In contrast, use of reclaimed water in domestic settings is likely to result in inhaled endotoxin exposures below the No Observed Effects Level (NOEL) even for reclaimed water without membrane filtration treatment.
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Prenatal exposure to levels of TFZ at approximately 400-fold below the reported no observed adverse effect level increased adipose depot weight.
Administration of TFZ to pregnant CD-1 mice during gestation at approximately 400-fold below the established no observed adverse effect level (NOAEL) led to increased adipose depot weight and promoted adipogenic gene expression in the MSC compartment while reducing the expression of bone markers in the prenatally exposed male offspring.
We conclude that bioaccumulation of alkylphenols is unlikely to be a major concern with respect to the recycling of sewage sludge to pasture because most recorded tissue values were below the estimated no observed adverse effect level (NOAEL) of approximately 500 μg/kg, on a dry matter basis (Müller and Schlatter 1998).
In fact, extensive review of the literature has demonstrated that below-NOEL (no observed effect level) responses are overwhelmingly more consistent with hormesis than with its rival models, including linear no-threshold (LNT) dose response (Calabrese and Baldwin 2001b, 2003).
The study focused on the combined oestrogenic effect and on thyroid hormone regulation: Simultaneous exposure below the effect level (no observed adverse effect concentration (NOAEC)) of the individual compounds did not lead to receptor activation.
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