The presented below pathway-based analysis corroborates with these findings and serves as a validation of the proposed BNKL methodology.
Below, the broad pathway leading from the surrounding moat and entry gate to the base of the rock fortress passes through a wonderful water garden, about half of which has been restored by archaeologists.
In discussing some of the key targets in the pathways below; we refer to the validated ones from miRecords and miRTarBase with [V] and predicted ones with [P].
Examination of the cobalamin synthesis pathway (described below, Figure 5) suggests Geobacter, as the dominant ∂-Proteobacterium in KB-1, is potentially capable of de novo cobalamin synthesis, but a TonB/BtuB complex may be an additional avenue for cobalamin acquisition.
Cytochrome c is part of the caspase-dependent intrinsic pathway discussed below and can interact with apoptotic protease activating factor-1 (Apaf-1) and procaspase 9 to form an apoptosome.
In evaluating the results below, mutator pathways are expected to predominate when α50% is at or below commonly observed values of α (ca. 10 500).
This might suggest divergence between multiple reflex pathways or the existence of primary and secondary cough afferent pathways (discussed below).
They are illustrated in Figure 1 and described in detail below: 1) definition of pathway signatures from compendium data (A-B); 2) calculation of mean correlations, r1... n, between disease profiles and n pathway signatures, and the statistical significance thereof (B-C); and 3) survival analysis on a patient dataset using each statistically significant r as a risk factor (C-D).
Cross-references to other Gramene modules, such as Genes, Markers/Sequences (see below) and Pathways (1) are also represented and are used to make other gene assignments to EC Number and terms from various ontologies including the Plant Ontology and Gene Ontology (22).
Other pathways discussed below may be alternatives for energy production.
The factors and pathways discussed below are depicted schematically in Fig. 2.
