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Using this threshold, we observed that a large proportion of driver mutations (92%) fell below our prediction threshold, whereas the vast majority of germ line polymorphisms (disease-causing/putative neutral mutations) and passenger mutations fell above our prediction threshold, 94 and 87%, respectively.
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The performance of our algorithm using our standard prediction threshold is documented in Supplementary Table S4.
The PWM model prediction score of 0.336 was below the prediction threshold (0.412) and had been assigned a low posterior probability of 0.117.
However, whereas the single nodal variant and most tip variants of "c-Jun bind 1" did not alter the binding motif prediction scores, the nodal and tip variants of "c-Jun bind 2" did reduce the scores below the prediction threshold in a similar manner to the CNRs, suggesting negative selection acting only on "c-Jun bind 1" (fig. 6 and supplementary table S4, Supplementary Material online).
Moreover, D (pos. -2) was validated as an allowed PTS1 tripeptide residue, even though the corresponding Arabidopsis sequence was scored slightly below prediction threshold (Table 1).
From streaming video services to mobile shopping, below are our predictions on what will cost less in the coming year.
That gets us below our toxic threshold.
This is well below our lower threshold of 40, although for reasons discussed below the absolute values of these thresholds should be interpreted with caution.
Thus, sub-lethal costs may have been incurred in our experiment, but remained below our detection threshold.
Nevertheless, we can not rule out the presence of pros transcripts in these NBs below our detection threshold.
Subsequent observation of averaged traces revealed significant averaged responses at intensities below our initial threshold estimate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com