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This latter finding indicates that increases in neuronal survival, serotonergic innervation and functional recovery (see below) observed in hMNP-transplanted animals were not due to tissue sparing, as they were absent in hFib-transplanted animals (Fig. 6).
We recognize that uncertainty increases as the dose response extrapolation extends farther below observed data.
The changes in metabolic processes and potential mitochondrial dysfunction (see below) observed in response to dichlorvos exposure make this a plausible mechanism for the damage induced in the worms.
In support of these trends, a recent mass spectrometry-based study (see below) observed significant enrichment for CCHC, CCCH and several smaller zinc finger families, but not C2H2 zinc fingers, in the mRNA-bound proteome [ 35].
Additional cohorts could be enrolled at higher or lower dose levels based on the number of dose-limiting toxicities (DLTs; described below) observed during the first 21 days in the current cohort of two patients, the cumulative toxicity rate at that dose combination, and the current doses of bosutinib and capecitabine.
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As discussed below, we observe primarily xSENP1a within early embryos.
While current doses are largely below those observed in the index case, our observation helps to better understand the effect of dioxin on the human immune system.
The monthly average extent for May 2016 is more than 1m sq km below that observed in May 2012.
Pd in the alloy may dissolve at potentials below those observed for the pure metal.
High infiltration rates measured at the micro-plots agreed with low intra-event runoff coefficients (mostly below 1%) observed under natural rainfalls at the hillslope.
