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The authors undertook a GWAS of ADHD and examined whether associated SNPs, including those below conventional levels of significance, influenced the same biological pathways affected by CNVs.
The only discrepancies in results were that 3 flares became non-significantly associated with a health utilities decrement (p = 0.31), and the associations between 1 3 flares and greater activity impairment (relative to no flares) fell below conventional levels of significance (1 2 flares: p = 0.051; 3 flares: p = 0.075).
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However these differences failed to reach conventional levels of significance.
More precisely, the null hypothesis that the model network has the same degree distribution as the data is not rejected on a Kolmogorov-Smirnov test at a p-value <0.01, far below the conventional level of statistical significance.
P values below the conventional level of statistical significance (P < 0.05) were considered statistically significant.
The majority of all individual probes (> 99.8%) for each sample met the commonly accepted quality control detection p-value of 0.01, indicating high quality data were obtained from both sample groups, but the analysis of blood spot DNA generally showed slightly higher mean detection p-values than buffy coat DNA, with fewer probes having a detection p-value below the conventional level of 0.01.
The latter effect is highly significant with a p-value below 0.002 while the motor effect is on verge of statistical significance using the conventional level of 5%.
Alpha was set to the conventional level of 0.05.
With the advent of antiretroviral therapy that can control virus replication below the detection levels of conventional assays, a new clinical landscape of AIDS emerged, in which non-AIDS complications prevail over AIDS-defining conditions.
It lacked the sensitivity of the conventional level.
A conventional significance level of p<0.05 was used.
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CEO of Professional Science Editing for Scientists @ prosciediting.com