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At tissue levels above 10−4 M, ROS including O2 are cytotoxic and may act as cell aging signals [ 22, 48]; below a tissue concentration of 10−5 M, ROS promote cell proliferation and tissue repair (granulation, neo-angiogenesis and epithelialisation) [ 22].
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This way, animals with a tissue concentration below the threshold can be grouped/pre-defined together with unexposed control animals, which potentially benefits clustering more than SVM.
This condition is probably met, because the tissue concentration of 5-HTP is below the Michaelis-Menten constant of AADC.
total non-displaceable tissue concentration.
a Tissue histamine concentrations after CLP (n = 8/group).
Because of known toxicity, the dose of lonafarnib administrated to these children may generate tissue concentrations below those necessary to obtain the effects we observed in vitro.
In 2 of the 3 years studied, there were detectable levels of NP in liver and muscle samples, but for each tissue concentrations were below detectable levels in one of the years, although not in the same year (Table 2).
Heavy metal elements, including Pb, Cd, and Zn, were also measured but are not discussed here because P. viridis tissue concentrations were at or below analytical limits of detection.
Na+ is able to stimulate growth of fungi and plants as long as the accumulation and compartmentalization are efficiently controlled below a limited concentration at the cell and tissue levels [ 6- 9].
Below a threshold concentration, the effect was absent.
Only use products that are labelled as being below a 1% concentration.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com