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U 2 for Y), λ U measures the probability that X is above a high quantile given that Y is also above that high quantile, while λ L measures the probability that X is below a low quantile given that Y is also below that low quantile.
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The regression on a low quantile ensures a minimal loss of true-positive sequences.
A low quantile for δ i thus strongly penalizes the overall score.
In other words, for each gene the samples are rank-ordered by DNA copy number and samples below the lowest quantile and above the highest quantile form two groups whose gene expression is compared with a modified t-test.
Conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of prostate cancer for the upper quantile groups compared with the lowest quantile as a reference group.
For equol, the subjects with values below the LOQ (n=238, 36%) were assigned to the lowest quantile, and the others were evenly divided into two groups.
U.S. counties in the lowest quantile of air quality had a higher fraction of non-Hispanic blacks and persons in poverty than did counties in the highest quantile of air quality for PM2.5 and ozone (Miranda et al. 2011).
Individuals in the highest versus the lowest quantile of sugar-sweetened beverage intake had a 26% greater risk of developing diabetes (119).
The pooled OR from all studies comparing highest with lowest quantile of 25(OH D was 0.67 (95% confidence interval [CI], 0.59 0.76), meaning there was a 33% lower risk associated with the highest compared with the lowest quantile of serum 25(OH D.
The lowest quantile of the serum 25(OH D concentration was generally < 20 ng/ml.
Because MDR works best with susceptibility factors that have only a few levels, and because we wanted to maintain comparability with the logistic regression analyses, age of exam was included in the model coded "1" for individuals in the lowest quantile of age of exam, "2" for those in the second quantile, and so on.
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