However, the radiation dose in these tissues should be kept below tolerance which means below the dose which creates clinically manifest severe damage.
The MTD was defined as a) the dose producing DLT in ≤ one out of 6 patients, or b) the dose level below the dose which produced DLT in ≥ one out of 3 patients, or in ≥ 2 out of 6 patients.
The MTD was defined as (a) the dose producing DLT in 2 out of 6 patients, or (b) the dose level below the dose which produced DLT in ≥ 2 out of 3 patients, or in ≥ 3 out of 6 patients.
For example, if the prescribed dose is 60 Gy, and the minimum dose (considered to be adequate) was 5% below the central dose (which was normalised to 100%), the treated volume is then enclosed by the 57 Gy isodose surface.
Chronic noncancer health effects have been assessed based on a threshold concentration or dose which is below a level at which no adverse health effects would occur.
The shortage of 99mTc from 2008 to 2009 with a temporary shift to more Tl imaging did not sustainably affect average patient dose, which is clearly below 10mSvv.
In this study, the concentrations of evacetrapib in 92% of patients were below detection 4 6 weeks after the last dose, which is consistent with the approximate 40-hour half-life observed for evacetrapib in the healthy subject studies.
The debate on the existence of a threshold dose (a dose below which there is no increase in an adverse response, and above which the adverse response increases) has important implications for risk assessment.
Interestingly, the 5 mg/kg troxacitabine dose, which was well below the maximum tolerated dose [ 5, 29, 30], resulted in tumor regressions occurring from Day 37 till Day 52 with mean tumor volumes of 133 mm3 to 97 mm3 (P < 0.001).
These models consider different level of doses, to establish a dose below which no effect occur to organs or system, or in extreme the death of an organism.
