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Due to strong and specific immunological responses, so called elite-controllers contain viral replication to levels below a clinically relevant threshold (<50 copies/ml) in the absence of cART (reviewed in [34]).
27 Thus, the apparent analgesic effect of acupuncture seems to be below a clinically relevant pain improvement.
Short term, one study was able to show an increases probability of reducing the depression score below a clinically relevant cut-point [ 36].
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As such, clinical benefit consisting of a partial response and/or disease stabilisation, that is, 'slowing' of disease progression could be a clinically relevant new parameter of efficacy.
In most cases for both spine pain and BASDAI score, the NNTs for etoricoxib were at least 0.5 units below those for naproxen, suggesting a clinically relevant difference favoring etoricoxib.
A figure 20% either side of the mean of the above and below cuff diameters was chosen to delineate the limits of a clinically relevant magnitude [ 13].
The COPM treatment effects for COPM performance of 1.4 -1.5 points are both below the cut-off value of 2 points (a 22%% change), being a clinically relevant change reported in the COPM manual [ 17].
These results confirmed that SC-derived NSCs yield benefit in a clinically relevant SCI model.
Ruiz, C. et al. Advancing a clinically relevant perspective of the clonal nature of cancer.
Our results showed that a clinically relevant dose of SLE suppressed melanoma growth in a mouse model.
Holden, N. J. et al. ANCA-stimulated neutrophils release BLyS and promote B cell survival: a clinically relevant cellular process.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com