Tolerance to the analgesic effect of opioids is believed to be mediated at least partly by prostaglandin-mediated mechanisms (Powell et al, 1999).
MPP+-mediated neurotoxicity is believed to be mediated by inhibition of complex I activity and excessive formation of reactive oxygen species (ROS) [ 1, 2, 14].
IgE mediated food allergy is believed to be mediated by type 2 T helper (Th2) cell responses to food allergens.
This change in insulin sensitivity is believed to be mediated directly by growth hormone binding to its receptor.
Gastrin has been shown to induce Shh production, processing and activity, which is believed to be mediated by acid secretion.
The mechanism of DCAN-induced carcinogenesis is believed to be mediated by oxidative bioactivation of DCAN molecules.
VLF power is correlated with long-term fluctuations of interbeat intervals and is believed to be mediated partly by the renin-angiotensin-aldosterone system [14].
To date, most of the cardiac effects of cell-based therapy are believed to be mediated by a local angiogenic response rather than by the formation of neosyncytial contractile units such as had initially been hoped for.
TZDs reduce resistin gene expression and this action is believed to be mediated through PPARγ [21].
MEK-dependent effects of BDNF are largely believed to be mediated through ERK activation [12].
In general, such heterosubtypic cross protection is largely believed to be mediated by cross reactive cell mediated immunity [9].
