However, we believe, beyond the primary scope of CONSORT for RCT and STROBE for observational studies, that in general, the abstracts reporting quality will benefit from the implementation of standardized criteria to improve the reporting quality, both in the abstract as well as in a potential subsequent full manuscript.
Below, we also address points 1b, 2, 4 and 5, which includes suggestions that we believe are beyond the scope of this study.
However, we will need to develop new reagents and seek a collaboration to perform high-resolution microscopy, which we believe lies beyond the scope of this paper and the appropriate time-frame for resubmission.
These results suggest that ROQUIN2 does not target AMPK in Tfh cell responses, and additional targets may play opposing roles on Tfh cells, but elucidation of the relevant ROQUIN2 actions to explain this effect we believe are beyond the scope of the current manuscript.
This is a good suggestion and one that should be addressed with future work, but we believe it is beyond the scope of the current manuscript.
Indeed we would love to do such an experiment, although accomplishing this is not trivial and furthermore we believe it is beyond the scope of this paper.
If authors believe they are beyond the scope of the current paper, perhaps, these questions should be mentioned in the discussion section as model generalizations/modifications that need to be performed in future studies.
Both points could be addressed by staining for multiple presynaptic protein markers and counting boutons in mice, however we believe this is beyond the scope of our current study.
However, because we do not have functional data to support that defects in epidermal integrity specifically induce proliferation/apoptosis (we believe this is beyond the scope of this paper), we have also toned down the language of our conclusion (the last sentence of the Results).
These studies could be undertaken, and we agree they would be worthwhile and likely to yield interesting results, but we believe they are beyond the scope of our present manuscript and would not possible to complete in the 2-month revision time frame.
