Given that obesity is associated with an increased risk of depression and reduced psychological well-being, 62 a potential mechanism of this association being weight stigma, 63 64 there may be a significant number of patients who are not offered support to lose weight, or with whom weight-related concerns are not discussed, suggesting compromised care for these patients.
The Russians had used DNP to keep soldiers warm in winter with the main side effect being weight loss.
Participants reported being weight stable (±2% body mass within the past 6 months), followed a standard sleep-wake cycle (for example, no shift workers) and did not anticipate changes in lifestyle (for example, diet/exercise) during the study period.
We also asked participants to describe three things they would like to change about themselves and categorised these responses as being weight and shape-related changes or face, skin and hair-related changes.
The frequency of side effects varied considerably among studies, the most frequent being weight loss, anorexia, abdominal pain, difficulties in concentrating, sedation and paresthesia.
The percentage of patients experiencing side effects varied greatly among the studies, the most common ones being weight loss (which, in the RCTs [10, 12], was present in 81 and 10.2% of patients, respectively), anorexia (23.8 and 13%, respectively), abdominal pain (14.3 and 10,2%), difficulties in concentrating, somnolence/sedation (19 and 8.3%) and paresthesia (23.8 and 8,3%).
