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The adapted module was then finalised before being used in Phase II.
Most clinical experience has been gained with the radioactive tracers 99 mTc-Annexin V [10, 11] and 99 mTc-6-hydrazinonicotinic [HYNIC]-radiolabeled Annexin V, the latter being used in phase II/III trials for determining the efficacy of chemotherapy in cancer patients [1].
Ki-67 expression is currently being used in phase II breast cancer chemoprevention trials.
The MTD was determined as 400 mg b.i.d., which is being used in Phase II studies to further assess safety and efficacy of BAY 43-9006 in a range of tumour types.
Another candidate for the intermediate outcome is time to culture conversion, which is increasingly being used in phase II trials and is arguably a more reliable surrogate endpoint than culture status at a single time point [ 24].
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Abgenix Chief Medicial Officer Gisela M. Schwab Gisela M. Schwab brags that in doses being used in phase-II clinical trials, 100% of patients using Abgenix's EGF drug developed this rash; no other side effects have been seen.
These results are being used in Phases 2 and 3 when developing and evaluating OPIS.
Adaptive allocation designs are used in phase III clinical trials.
Only bio-carrier was used in Phase I without suspended sludge.
In experiment II, two schedules were used in phase 1, and the same protocol used in experiment I was followed.
They should thus be used in phase 2 and 3 trials to show that altering the pathophysiological mechanism of the disease affects the clinical status [10].
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