Sentence examples for being under negative selection from inspiring English sources
Two of the site-specific methods also yielded evidence of a single codon, at position 99, being under negative selection.
All except one of the conserved cysteine residues are implicated as being under negative selection in both primate and mouse lineages.
In contrast, 10.0% of sites within the IDR (3 of 30, not including the initiator Met codon) and 36.4% of sites within the body of the polypeptide (104 of 286) were identified as being under negative selection.
At the individual codon level, we found 99 residues were under negative selection in MYB genes without a single positively selected residue.
Substitutions that deleteriously affect the affinity, specificity and selectivity of a beneficial motif will generally be under negative selection and will fail to spread through the population.
The authors also found a correlation between genes predicted to be under negative selection and genes implicated in certain hereditary diseases.
For example, among the genes the researchers predicted to be under negative selection are those involved in muscular dystrophy and in Usher syndrome, the most common cause of congenital blindness and deafness in developed countries.
They claim that the likely reason that these virulence factors are under negative selection is that they lead to immune evasion (the immune system targets the virulence factors).
It is clear that both CHR-O and N-CHR homologous groups are under negative selection.
Besides, even though all the sites in a protein are under negative selection, various negative selection pressures still may appear in different domains in a protein.
