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They are currently being treated with multiple antibiotics and additional surgeries.
An insulin pump was being used by 171 (80%), the others being treated with multiple daily injections of insulin.
Identification of a resistance pathway could result in patients being treated with multiple drugs to concurrently block multiple pathways.
Insulin pump therapy was the treatment modality in 190 (82%) subjects, with the others being treated with multiple daily injections.
The RealTrend study was a 6-month, randomized, parallel-group, two-arm, open-label study of 132 adults and children with uncontrolled type 1 diabetes (A1C ≥8%) being treated with multiple daily injections.
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In insulin-treated patients with T1DM, 23.3% were treated with conventional therapy, 66% were treated with multiple daily injections, and 10.7% were treated with CSII 1 year after diabetes diagnosis.
Women were treated with multiple insulin injections aiming at normoglycaemia.
Male Sprague Dawley rats were treated with multiple doses of minocycline (45 mg/kg i.p).
A 73-year-old male complained of a small ulcer on his left toe, which was treated with multiple endovascular therapy.
The patient had been treated with multiple antipsychotic drugs including SDAs and DPAs, which may cause NMS, and had a history of an oral MARTA-induced increase in CK, resulting in withdrawal of the drug.
Because older patients tend to be treated with multiple medications for multiple comorbidities, it becomes challenging to design regimens that avoid or reduce the risk of drug drug interactions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com