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Different mechanisms such as point mutations, recombinations and gene conversions frequently introduce new HLA variants in human populations [ 29, 30], the generation of new alleles (i.e. defined at 2nd-field level of resolution or above, according to the official nomenclature) being thus difficult to model.
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Diagnosis and indications for surgery are thus difficult to establish.
It is thus difficult to know who makes or receives what.
Their respective effects on biodiversity are thus difficult to disentangle and are poorly understood.
It is thus difficult to design liquid crystal displays with flexible substrates.
The respective reproductive functions of fish LH and FSH are thus difficult to establish.
It is thus difficult to generalize about the relation of foreign trade to economic growth.
Some have sneaked across the river and are thus difficult to count.
It is thus difficult to say whether this target implies a meaningful price for carbon.
It is thus difficult to evaluate his assertion that "the United States more than any other country will shape the future of the amazing developments in international human rights".
Scientists and engineers generally tackle problems that include multiscale effects and that are thus difficult to solve numerically.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com