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This is possibly related to them also being the most conserved of the var genes.
Non-coding regions are most variable, followed by PCGs and rRNA genes, with tRNA genes being the most conserved (Table 2).
Members of the ANTH family are also found in most taxa excluding the Chromista and Excavata, with the PICALM subfamily composed of Metazoa AP180 and CALM and Fungi yAP1801-2 being the most conserved.
The multiple alignment consisted of 721 positions, of which 358 were conserved (46.9%), with domain III being the most conserved region (61.1%).
These profiles assign each residue to one of nine conservation levels, with 9 being the most conserved and 1 being the most variable.
Overall sequence similarity across the KAP-β family is low, at about 15 20%, with the N-terminal portion of the KAP-β protein, which binds the small GTPase Ran, being the most conserved region [9].
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Additionally, CS responses in ciprofloxacin-resistant mutants were the most conserved in our dataset, with CS to gentamicin occurring in 8 of 10 strains and CS to fosfomycin in 7 of 10 strains (Fig. 1a).
Regions corresponding to α-helices are predicted to be very rigid, and are the most conserved.
The MTCM1 motif is the most conserved segment within the 54-bp repeat units.
Among motif subgroups the occurrences and preferences of 6folds appear to be the most conserved.
The next most common motif was Motif S4, in which Trp and Leu were the most conserved.
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