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Although molecular descriptor based methods are computationally simple and effective in practice but they share several shortcomings most important being the inability to identify local similarity between structures.
Detection of nonnormal heart function in the left ventricle (LV), for instance, can cause systolic dysfunction, being the reduction in the ability to contract, or diastolic dysfunction, being the inability to fill efficiently.
Most women surveyed said they had a negative experience giving birth while incarcerated, with their main complaint being the inability to have a support person in the hospital with them.
Ecologic studies are another type of study, with the major limitation being the inability to characterize exposure data to individuals (see "Exposure Definition").
> -wrap-foot> Reference-based metannotationnotation by comparison with known sequences is essential but has drawbacks, with the biggest limitation being the inability to annotate novel sequences.
These epidemiological studies, however, are liable to a number of inherent weaknesses in study design, the main limitation being the inability to control for confounding factors which importantly included weight, duration of diabetes and smoking in some instances.
Similar(53)
"The problem is the inability to export.
Boredom is the inability to start something.
"The issue is not the inability to plan, it is the inability to save.
Infertility is the inability to achieve a normal pregnancy.
As Dostoevsky said: "Hell is the inability to love".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com