MCODE retrieved 109 modules, with module 1 (M1) being the highest ranked (i.e., greatest connectivity in the network).
It can be seen that the highest connectivity TFs varied from one functional group to another - STAT3 had 39 connections in Development, p53 had 26 connections in DNA Damage, (iii) c-Jun had 12 connections in Apoptosis and Survival, (iv) GATA-1 had 5 connections in Cytoskeleton Remodeling, and (v) c-Myc had 2 connections in Cell Adhesion.
Of the 7 genes, HTR4 and GCH1 are "hubs" showing the highest "connectivity" with other components within the network.
We point out that in general that regardless of the overall structure, the major trend is that the high connectivity genes are few in number, and that most genes have low connectivity.
One such strategy was a targeted immunization wherein nodes having the highest connectivity were deemed to be the most critical for spreading the infection, and hence those highly connected people were chosen for vaccination [8].
A cumulative forest plot is defined: genes are added to the signature, one by one, in order of their connectivity, C, score so that genes that are introduced first have the highest connectivity.
Among the 23 major cities selected, Shanghai is revealed to have the highest connectivity level, leading in both air and rail connectivity.
Accordingly, the lower the dissimilarity is, the higher the connectivity is and vice versa.
Based on this understanding, an automated strategy could be pursued to progressively reclassify the highest connectivity internal metabolites as external until there is a sharp drop in the p value calculated from equation (1.15).
Another principal distinction between the C. elegans nervous system and the brains of higher organisms such as human beings
