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The video for Love Will Never Do (Without You) is notable for being the first instance of Jackson's transition into sexual imagery and midriff-baring style, becoming her trademark.
Though lesbian vampire flicks may have made themselves redundant thanks to constantly reinterpreting J. Sheridan Le Fanu's Carmilla (which is known for being the first instance of lesbian vampires in fiction), many of these films express their own distinct complexity.
A consensus of opinion exists as to Time Zero being the first instance where severe sepsis is present.
The organization of health care in Blekinge focuses on the PHC as always being the first instance of contact with health care for the inhabitants, except in cases of acute and severe disease or trauma.
The recent demonstration of efficacy of a CFTR potentiator in patients carrying at least one copy of G551D CFTR was a quantum leap for CF therapy, being the first instance of a therapeutic intervention based on a small molecule that directly targets the mutant gene product.
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This is the first instance where it's not hypothetical.
This is the first instance of an interpolation theorem which holds for a subinterval of 0<θ<1.
This is the first instance of an electrochemical report for this family of heterocycles.
Frame-structured knowledge bases are the first instance seen as object-oriented representation.
Sadat's visit to Jerusalem was the first instance where the "textbook history" was interrupted.
This would not be the first instance in which the National Guard has been invoked in Chicago.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com