Similarly, the safety and tolerability of 177Lu-DOTA-JR11, also known as 177Lu-OPS201, is currently being tested in phase I/II clinical trials for NET patients (NCT02592707).
Because PARP inhibitors enhance oxidative metabolism and improve metabolic flexibility, these compounds are being tested in phase III trials as anti-cancer agents [6, 86].
Building on these successes and strong preclinical work, other signal transduction inhibitors are being tested in phase I and phase II clinical trials.
Currently, CPI-613 is being tested in phase I and II clinical trials, as a single agent or in combination with standard chemotherapy, to treat cancers (NCT02168140, NCT01902381, NCT02232152, and NCT01766219).
Several molecular predictors for prognosis (MammaPrint® or Oncotype DX) and drug prediction (DLD30, SET index) have been generated using DNA-based arrays or RT-PCR, some of these being tested in phase III trials.
In addition, the hypothesis that PF plus a taxane may result in an improved survival, compared to PF alone, for patients with locally advanced SCCHN on ST treatments is being tested in phase III trials.
Fexinidazole, an old drug rediscovered for this purpose is being tested in phase 2 clinical trials.
The vaccine, co-developed by the National Institutes of Health in the United States and Okairos, a biotechnology firm acquired by GSK in 2013, is now being tested in phase I safety trials in Britain, the United States, Switzerland and Mali involving around 200 healthy volunteers in total.
Currently recombinant human TRAIL is being tested in phase I clinical trials.
Currently, VEGF-Trap is being tested in phase III clinical trials in a number of tumor types [6].
Given that LBH589 shows anticancer activity in preclinical pancreatic cancer models [28] as well that the tumor-selective TRAIL is a potential cancer therapeutic protein and is being tested in phase I clinical trials, our findings warrant further evaluation on the combination of LBH589 and TRAIL as a potential therapeutic regimens against pancreatic cancer in animal models and in clinical trials.
