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Adeno-associated viral (AAV) vectors are currently being tested in multiple clinical trials for liver-directed gene transfer to treat the bleeding disorders hemophilia A and B and metabolic disorders.
Currently, this agent is being tested in multiple fields of periodontology from recession coverage to vertical bone augmentation and the reconstruction of peri-implant defects.
Preliminary studies suggest that PF may also decrease adverse effects of chemotherapy in humans (Safdie et al., 2009), a finding now being tested in multiple larger randomized clinical trials.
Two monoclonal antibodies are being tested in multiple myeloma (daratumumab, identifier: NCT00574288 and MOR03087, identifier: NCT01421186; http://clinicaltrials.gov) and a third in selected CD38+ hematological malignancies including CLL (SAR650984, identifier: NCT01084252; http://clinicaltrials.gov).gov
The newly developed bromodomain inhibitors that have shown dramatic efficacy in hematological malignancies [ 140, 141] are now being tested in multiple clinical trials for NUT midline carcinoma characterized by BRD3/ 4-NUT gene fusions, which represent a rare but highly aggressive class of tumors with no effective treatment currently available [ 104].
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Here we describe the development of the SYN-004 enteric coated pellet formulation, which has been tested in multiple clinical trials.
The abstractions generated by ALPINE are tested in multiple domains on large problem sets and are shown to produce shorter solutions with significantly less search than planning without using abstraction.
The correspondence was tested in multiple domains including gene expression experiments, stock trade records and functional protein families.
Conversely, from a statistical viewpoint, when a data set is tested in multiple angles, the threshold for statistical significance should be adjusted to reduce the inflated type I error.
To determine the independent parameters correlated with CAI and A-FABP, parameters including age, gender, and those correlated significantly with CAI and A-FABP in correlation analysis were tested in multiple stepwise regression analysis.
Further multiple primer sets were tested in multiple conditions (data not shown).
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