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Several PET-response-guided therapy regimens have already been established, and even more PET-adapted study designs are being tested in large study groups.
Specific gene signatures have been identified that correlate with different aspects of the disease, including two risk-predictors for distant recurrence that are currently being tested in large clinical trials [8] [12].
Table 4 describes selected compounds that are being tested in large phase 2/3 studies.
Two of these signatures have already been developed for commercialization as centralized laboratory tests and are presently being tested in large prospective trials.
Anti-angiogenic agents are now being tested in large multi-institutional phase III trials for subjects with early stage HCC, as an adjunct to TACE, RFA, and resection.
Furthermore, the clinical feasibility of incorporating CYP2C9 and VKORC1 genotyping-based COAs dosing regimens into routine clinical practice is being tested in large prospective clinical trials [ 9– 11].
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It was being tested in large-scale human trials for the treatment of cytomegalovirus and adenovirus infections, and had received FDA's "fast track" designation for CMV, adenovirus and smallpox when FDA approval came for use of the drug on Ebola patients.
While these small studies are not conclusive, they show trends that would be well served by being tested in larger, powered trials.
Some experts believe that other formulations may yield different results, but they have yet to be tested in large randomized clinical trials, and until they are there is no way to know.
Experts said the findings were interesting and called for the idea to be tested in large trials.
Clazosentan, magnesium, and simvastatin have been tested in large high-quality trials but failed to show a beneficial effect.
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