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At times it is visibly being strained for: at Ferndale, in northern California, the land of the redwoods, lies Knud Hansen, laid to rest there in 1904,...a Woodman of the World a sonorous phrase of no obvious meaning whatever.
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So Huddersfield are up and running, Wigan Warriors have cleared off to Auckland before the World Club Challenge and the other 12 Super League clubs are straining at the leash for the second phase of the competition's split opening round.
For each assay, strains were grown for at least five generations with no strain entering starvation or encountering dauer-inducing conditions.
To insure differences in resistance and life-history traits between the four strains were not due to maternal effects, each strain was reared for at least two generations in standard laboratory conditions without insecticide selection, before experiments began.
Both driver strains were crossed for at least ten generations into FVB/NJ background before crossing them with mice carrying the Trpml3lox allele.
Sixty-six strains were sequenced for at least one genetic marker.
The majority of these strains were positive for at least one virulence factor.
All strains were backcrossed for at least 10 generations to the C57Bl/6 background.
All mouse strains were backcrossed for at least seven generations to obtain a more than 99% homogeneous FVB background.
All strains were backcrossed for at least nine generations on to the B6 background and were maintained under specific pathogen free conditions at the University of Glasgow animal facilities, before being used between 6 and 12 weeks of age.
Their relative absence is a strain for many species at the top of the world.
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