Sentence examples for being required for localized from inspiring English sources

Furthermore, NADPH oxidases are now recognized to have specific subcellular localizations, thus being required for localized ROS production [ 22].

Mechanistically, ILK is required for localizing IQGAP1 to the cell cortex, which then, together with mDia1, regulates local stability of MTs.

This gene is required for localizing pole plasm and specifying germ cells [10], [12].

The gustavus gene is required for localizing pole plasm and specifying germ cells.

These data suggest that TRF2 is required for localizing SLX4 at telomeres.

Structure-function analysis of Spn-F demonstrated that its dynein-binding region is required for localizing IKKε to the distal tip and for bristle morphogenesis.

The authors were able to identify a plausible mechanism, showing that MRJ-L colocalizes with Vpr and is required for localizing Vpr to the nucleus.

Nok and Ome are clearly localized apically in the retinal epithelium at 28 hpf (Wei and Malicki, 2002; Omori and Malicki, 2006), raising the question whether they are required for localizing RFP-lin7c.

Future studies will have to reconcile the potential functions of these ligand-independent forms, with our recent findings that ligand binding is required for localizing CTLA-4 to the immunological synapse [ 3].

8 The interaction between PALB2 and BRCA2 is required for localizing and stabilizing of BRCA2 to sites of DNA damage by chromatin association. 3, 9 Loss of PALB2 has been found to abolish BRCA2 focus formation and the ability of the latter to regulate HR repair of double-strand breaks through its direct interaction with RAD51.

These findings clearly demonstrate that Zfp277 is required for PRC1 to localize to and repress the Ink4a/Arf locus and suggest that impaired binding of PRC1 to the Ink4a/Arf locus is the primary cause of the derepression which subsequently induces premature senescence in Zfp277−/− MEFs.