Further, is now appreciated that androgen independent CaP is relatively refractory to in situ therapies.
However, subcutaneous tumors are relatively refractory and have required maximally tolerated doses of cells.
In contrast to bovine explant models which effectively respond to recombinant human IL-1β, canine models are relatively refractory to human IL-1β stimulation.
Such reconstruction might still be possible if the subset of genes conserved among all genomes in a group (or common to all genomes) comprise a core that is relatively refractory to LGT.
More importantly, exposure of primary cells derived from lymphoma patients (n = 12) showed dose-dependent sensitivity to C1, whereas cells from non-cancerous lymph nodes were relatively refractory to the treatment (Figure 4C).
Primary human monocytes are relatively refractory to single round infection or full replication of HIV-1 [3], [3], albeit efficient infection of monocytes, DCs or macrophages can be achieved by using high amounts of input virus [23], [32], [33].
Compared to more differentiated cells of the hematopoietic lineage such as macrophages or dendritic cells (DCs), human primary monocytes are relatively refractory to HIV-1 infection in vitro [1], [2].
Based on the microarray data and cytotoxic effects, it appears that diploid cells are relatively refractory to the apoptosis-inducing and to the transcriptome-modifying effects of Chk1 inhibition (as compared to tetraploid cells), while tetraploid cells are relatively resistant against the cytocidal and transcriptional effect of cisplatin (as compared to diploid cells).
We demonstrate that CD8α+ DCs are the most susceptible to infection ex vivo and the only subset capable of priming antigen specific T cells to Lm. CD11b+ DCs, while elaborating cytokines in response to infection, did not elicit a strong CD8 T cell response, and PDCs were relatively refractory to infection ex vivo.
