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The rapid induction of FGFR2 and FGFR3 mRNA suggests that the fgfr2 and fgfr3 genes are not amplified but are being regulated at the transcriptional level.
To address the likelihood of Survivin being regulated at the transcription level during apoptosis, we performed semiquantitative reverse transcription-PCR.
The activity of eNOS - as an example for a gene that is being regulated at the epigenomic level - can be reduced by histone deacetylase (HDAC) inhibitors, which consequently results in reduced vasorelaxation [ 52].
Furthermore, the generation of vasoinhibins at the target tissue level represents a novel example of paracrinology, an exciting concept in endocrinology by which hormone action is being regulated at the target tissue microenvironment (56).
We definitively show that all genes have the potential of being regulated at the promoter proximal pause site, as all initiated Pol II undergoes a P-TEFb dependent step of escape into productive elongation.
It is also important to note that most of the cells we identified as having low levels of Mre11 protein had relatively normal levels of MRN mRNA suggesting that, like HCT116, they may contain a defective protein rather than the level of protein being regulated at the transcriptional level.
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In addition, for some lines of insurance, pricing is regulated at the state level, with regulators controlling how much a company charges for a given product.
Instead of the UK deciding on the regulation of – for example – cleaning products, cleaning products are regulated at the European level.
"We do think in the end this needs to be regulated at the federal level rather than as a patchwork of state regulations," she said.
By an accident of history, utilities, like insurance companies, are regulated at the state level.
The Treasury has said life insurers must be affiliated with banks or thrifts that are regulated at the federal level.
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